Abstract Backgroud: Previous studies have identified B cell subpopulations with pro- and anti-tumoral activities, while the clinical relevance of B…
Abstract Background: Although numerous studies have shown that the expression and activation of TRPV1 have an important role in cancer…
Abstract Background: Intratumor heterogeneity (ITH) is associated with tumor progression, unfavorable prognosis, immunosuppression, genomic instability, and therapeutic resistance. Thus, evaluation…
Keywords: Spliceosome pathway, Pan-cancer, Anti-tumor immunity, Cancer immunotherapy, Drug response, Genomic instability Authors: Zuobing Chen, Canping Chen, Lin Li, Tianfang…
Abstract Intratumor heterogeneity (ITH) is a biomarker of tumor progression, metastasis, and immune evasion. Previous studies evaluated ITH mostly based…
Keywords: Cancer, Microsatellite instability, Gene expression profiling, Machine learning, Algorithm, Classification, AUC, area under the curve, CV, cross validation, GEO,…
Abstract Background: Tumor mutation burden (TMB) has been associated with cancer immunotherapeutic response and cancer prognosis. Although many explorations have…
Abstract Background: PLK1 overexpression is oncogenic and is associated with poor prognosis in various cancers. However, the current PLK1 inhibitors…
Abstract Background: The Cancer Genome Atlas (TCGA) is an important data resource for cancer biologists and oncologists. However, a lack…
Abstract The homogeneity and heterogeneity in somatic mutations, copy number alterations and methylation across different cancer types have been extensively…