Reactivation of Multiple Fetal miRNAs in Lung Adenocarcinoma
Abstract Simple Summary: Patterns of microRNA expression in fetal tissues are not well-characterized, due to the rarity of human fetal…
Wan L. Lam
Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology
Abstract Human PIWI-interacting RNAs (piRNAs) are known to be expressed in germline cells, functionally silencing LINEs and SINEs. Their expression…
Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer
Abstract The NFE2-related factor 2 (NRF2) pathway is critical to initiate responses to oxidative stress; however, constitutive activation occurs in…
SOX15 and other SOX family members are important mediators of tumorigenesis in multiple cancer types
Abstract SOX genes are transcription factors with important roles in embryonic development and carcinogenesis. The SOX family of 20 genes…