Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
Abstract Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of…
Trevor J. Rutherford
Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control
Abstract Transcriptional silencing through the Polycomb silencing machinery utilizes a “read-write” mechanism involving histone tail modifications. However, nucleation of silencing…
Engineering a two-helix bundle protein for folding studies
Abstract The SAP domain from the Saccharomyces cerevisiae THO1 protein contains a hydrophobic core and just two α-helices. It could…
Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53
Abstract Human mitochondrial transcription factor A (TFAM) is a multi-functional protein, involved in different aspects of maintaining mitochondrial genome integrity.…