The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Abstract Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share…
Abstract Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported.…
Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR…
Abstract Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation…
Abstract Electronic supplementary material: The online version of this article (10.1007/s10858-019-00248-2) contains supplementary material, which is available to authorized users.…
Abstract Characterisation of the structure and dynamics of large biomolecules and biomolecular complexes by NMR spectroscopy is hampered by increasing…