The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Tobias Madl
FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
Abstract Transcription factors play key roles in orchestrating a plethora of cellular mechanisms and controlling cellular homeostasis. Transcription factors share…
EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner
Abstract Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported.…
p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR
Abstract The most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) is the presence of poly-PR/GR…
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
Abstract Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation…
NMR characterization of solvent accessibility and transient structure in intrinsically disordered proteins
Abstract Electronic supplementary material: The online version of this article (10.1007/s10858-019-00248-2) contains supplementary material, which is available to authorized users.…
Studying the Structure and Dynamics of Biomolecules by Using Soluble Paramagnetic Probes
Abstract Characterisation of the structure and dynamics of large biomolecules and biomolecular complexes by NMR spectroscopy is hampered by increasing…