Neural basis of adolescent THC-induced potentiation of opioid responses later in life
Abstract Use of one addictive drug typically influences the behavioral response to other drugs, either administered at the same time…
Stephen V. Mahler
Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats
Abstract Rationale: Adolescent cannabis use is linked to later-life changes in cognition, learning, and memory. Rodent experimental studies suggest Δ9-tetrahydrocannabinol…
Long-term effects of THC exposure on reward learning and motivated behavior in adolescent and adult male rats
Abstract Rationale: The endocannabinoid system makes critical contributions to reward processing, motivation, and behavioral control. Repeated exposure to THC or…
Endocannabinoid-Enhanced “Liking” in Nucleus Accumbens Shell Hedonic Hotspot Requires Endogenous Opioid Signals
Abstract Introduction: Stimulating either endogenous cannabinoids or opioids within a restricted dorsomedial “hedonic hotspot” in nucleus accumbens (NAc) shell enhances…