Abstract Purpose: Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells…
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s00401-022-02483-8. Article type: Research Article Keywords: Progressive supranuclear palsy,…
Abstract Primary 4‐repeat tauopathies with frontotemporal lobar degeneration (FTLD) like Progressive Supranuclear Palsy (PSP) or Corticobasal Degeneration (CBD) show diverse…
Abstract Corticobasal degeneration (CBD) is a neurodegenerative disorder affecting movement and cognition, definitively diagnosed only at autopsy. Here, we conduct…