Quantifying the Kinetics of Signaling and Arrestin Recruitment by Nervous System G-Protein Coupled Receptors
Abstract Neurons integrate inputs over different time and space scales. Fast excitatory synapses at boutons (ms and μm), and slow…
Shivani Sachdev
Differential activation of G protein‐mediated signaling by synthetic cannabinoid receptor agonists
Abstract Synthetic cannabinoid receptor agonists (SCRAs) are new psychoactive substances associated with acute intoxication and even death. However, the molecular…
Brodifacoum does not modulate human cannabinoid receptor-mediated hyperpolarization of AtT20 cells or inhibition of adenylyl cyclase in HEK 293 cells
Abstract Background: Synthetic cannabinoids are a commonly used class of recreational drugs that can have significant adverse effects. There have…
Absence of Entourage: Terpenoids Commonly Found in Cannabis sativa Do Not Modulate the Functional Activity of Δ9-THC at Human CB1 and CB2 Receptors
Abstract Introduction: Compounds present in Cannabis sativa such as phytocannabinoids and terpenoids may act in concert to elicit therapeutic effects.…