Small molecule inhibitors targeting Polycomb Repressive Complex 1 RING domain
Abstract Polycomb repressive complex 1 (PRC1) is an essential chromatin modifying complex that monoubiquitinates histone H2A and is involved in…
Shihan He
BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization
Abstract BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of…