Prenatal cannabis smoke exposure alters placental development in a murine model of pregnancy
Abstract Cannabis use during pregnancy continues to increase with smoking remaining the most common mode of consumption. While clinical studies…
Sandeep Raha
Cannabis smoke extract disrupts trophoblast differentiation and causes mitochondrial dysfunction beyond the effects of Δ9-THC alone
Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-026-36939-8. Article type: Research Article Keywords: Cannabis smoke extract,…
Cannabidiol Disrupts Mitochondrial Respiration and Metabolism and Dysregulates Trophoblast Cell Differentiation
Abstract Trophoblast differentiation is a crucial process in the formation of the placenta where cytotrophoblasts (CTs) differentiate and fuse to…
The Implications of Cannabinoid-Induced Metabolic Dysregulation for Cellular Differentiation and Growth
Abstract The endocannabinoid system (ECS) governs and coordinates several physiological processes through an integrated signaling network, which is responsible for…
Effect of Delta-9-tetrahydrocannabinol and cannabidiol on milk proteins and lipid levels in HC11 cells
Abstract Pregnant and lactating women have been discouraged from using cannabis by Health Canada. However, the increasing rate of cannabis…
The Impact of Early Life Exposure to Cannabis: The Role of the Endocannabinoid System
Abstract Cannabis use during pregnancy has continued to rise, particularly in developed countries, as a result of the trend towards…
Cannabinoid Signalling in Immune–Reproductive Crosstalk during Human Pregnancy
Abstract Despite the intricate involvement of the endocannabinoid system in various physiological processes, it remains one of the most under-studied…
Delta-9-tetrahydrocannabinol inhibits invasion of HTR8/SVneo human extravillous trophoblast cells and negatively impacts mitochondrial function
Abstract Prenatal cannabis use is a significant problem and poses important health risks for the developing fetus. The molecular mechanisms…
Delta‐9‐tetrahydrocannabinol disrupts mitochondrial function and attenuates syncytialization in human placental BeWo cells
Abstract The psychoactive component in cannabis, delta‐9‐tetrahydrocannabinol, can restrict fetal growth and development. Delta‐9‐tetrahydrocannabinol has been shown to negatively impact…
Transcriptomic and functional analyses of 3D placental extravillous trophoblast spheroids
Abstract Placental extravillous trophoblast (EVT) invasion is essential in establishing proper blood supply to the fetus during pregnancy. However, traditional…