Cannabinoids and the endocannabinoid system in immunotherapy: helpful or harmful?
Abstract Numerous studies in various cancer models have demonstrated that ingredients of cannabis can influence tumor growth through the endocannabinoid…
Rudolf Schicho
Cannabinoid receptor 2 plays a pro-tumorigenic role in non-small cell lung cancer by limiting anti-tumor activity of CD8+ T and NK cells
Abstract Cannabinoid (CB) receptors (CB1 and CB2) are expressed on cancer cells and their expression influences carcinogenesis in various tumor…
The Immune Endocannabinoid System of the Tumor Microenvironment
Abstract Leukocytes are part of the tumor microenvironment (TME) and are critical determinants of tumor progression. Because of the immunoregulatory…
Cannabinoids and Opioids in the Treatment of Inflammatory Bowel Diseases
Abstract In traditional medicine, Cannabis sativa has been prescribed for a variety of diseases. Today, the plant is largely known…
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice
Abstract Objective: The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI)…
A potential role for GPR55 in gastrointestinal functions
Abstract ► GPR55 is a putative cannabinoid receptor. ► GPR55 shares little homology (10–15%) with cannabinoid-1 (CB1) and cannabinoid-2 (CB2)…