FUS driven circCNOT6L biogenesis in mouse and human spermatozoa supports zygote development
Abstract Circular RNA (circRNA) biogenesis requires a backsplicing reaction, promoted by inverted repeats in cis-flanking sequences and trans factors, such…
Riccardo Pierantoni
The Cannabinoid Receptor CB1 Stabilizes Sperm Chromatin Condensation Status During Epididymal Transit by Promoting Disulphide Bond Formation
Abstract The cannabinoid receptor CB1 regulates differentiation of spermatids. We recently characterized spermatozoa from caput epididymis of CB1-knock-out mice and…
The Epigenetics of the Endocannabinoid System
Abstract The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and…
Endocannabinoids are Involved in Male Vertebrate Reproduction: Regulatory Mechanisms at Central and Gonadal Level
Abstract Endocannabinoids (eCBs) are natural lipids regulating a large array of physiological functions and behaviors in vertebrates. The eCB system…
Cannabinoids and Reproduction: A Lasting and Intriguing History
Abstract Starting from an historical overview of lasting Cannabis use over the centuries, we will focus on a description of…