A pan-cancer analysis implicates human NKIRAS1 as a tumor-suppressor gene
Abstract κB-Ras proteins inhibit two signaling pathways known to be important for carcinogenesis: NF-κB, a key regulator of inflammation, and…
Raul Rabadan
Secretome analysis of patient-derived GBM tumor spheres identifies midkine as a potent therapeutic target
Abstract Glioblastoma (GBM) is the most lethal primary brain tumor with few treatment options. The survival of glioma-initiating cells (GICs)…
A pan-cancer analysis of driver gene mutations, DNA methylation and gene expressions reveals that chromatin remodeling is a major mechanism inducing global changes in cancer epigenomes
Abstract Background: Recent large-scale cancer sequencing studies have discovered many novel cancer driver genes (CDGs) in human cancers. Some studies…