Endocannabinoid basis of personality—Insights from animal model of social behavior
Abstract Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns.…
Raphael Mechoulam
Novel Synthesis of C-Methylated Phytocannabinoids Bearing Anti-inflammatory Properties
Abstract There is growing interest in non-psychoactive phytocannabinoids, namely cannabidiol (CBD), cannabigerol (CBG), and cannabichromene, as potential leads for novel…
Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats
Abstract The pathophysiology of major depressive disorder (MDD) is diverse and multi-factorial, yet treatment strategies remain limited. While women are…
Maintained anxiolytic effects of cannabidiol after treatment discontinuation in healthcare workers during the COVID-19 pandemic
Abstract Objective: To assess whether the effects of oral administration of 300 mg of Cannabidiol (CBD) for 28 days on…
Adherence, Safety, and Effectiveness of Medical Cannabis and Epidemiological Characteristics of the Patient Population: A Prospective Study
Abstract Background: Despite the absence of rigorous prospective studies, there has been an increase in the use of cannabis-based medicinal…
Novel CBG Derivatives Can Reduce Inflammation, Pain and Obesity
Abstract Interest in CBG (cannabigerol) has been growing in the past few years, due to its anti-inflammatory properties and other…
Efficacy and Safety of Cannabidiol Plus Standard Care vs Standard Care Alone for the Treatment of Emotional Exhaustion and Burnout Among Frontline Health Care Workers During the COVID-19 Pandemic
Abstract Question: Is cannabidiol (CBD) therapy capable of reducing emotional exhaustion and burnout symptoms among frontline health care professionals working…
Assessing the treatment of cannabidiolic acid methyl ester: a stable synthetic analogue of cannabidiolic acid on c-Fos and NeuN expression in the hypothalamus of rats
Abstract Background: Cannabidiol (CBD), the non-psychotropic compound from Cannabis sativa, shows positive results on controlling several health disturbances; however, comparable…
Cannabinoid Quinones—A Review and Novel Observations
Abstract A cannabinoid anticancer para-quinone, HU-331, which was synthesized by our group five decades ago, was shown to have very…
Anti-Biofilm Activity of Cannabidiol against Candida albicans
Abstract Candida albicans is a common fungal pathogen in humans. Biofilm formation is an important virulence factor of C. albicans…