A Male Mouse Model of WIN 55,212–2 Self-Administration to Study Cannabinoid Addiction
Abstract Despite substantial progress in preclinical cannabinoid research, translational studies on cannabis use disorders (CUD) are still insufficient due to…
Rafael Maldonado
Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials
Abstract Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of…
THC exposure during adolescence increases impulsivity-like behavior in adulthood in a WIN 55,212-2 self-administration mouse model
Abstract Background: Cannabis addiction is a chronically relapsing disorder lacking effective treatment. Regular cannabis consumption typically begins during adolescence, and…
A male mouse model of WIN 55,212–2 self-administration to study cannabinoid addiction
Abstract We have established for the first time a mouse model of cannabinoid addiction using WIN 55,212–2 intravenous self-administration (0.0125…
Orally Active Peptide Vector Allows Using Cannabis to Fight Pain While Avoiding Side Effects
Abstract The activation of cannabinoid CB1 receptors (CB1R) by Δ9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, induces analgesia. CB1R…
The endocannabinoid system in modulating fear, anxiety, and stress
Abstract The endocannabinoid system is widely expressed in the limbic system, prefrontal cortical areas, and brain structures regulating neuroendocrine stress…
Early 5‐HT 6 receptor blockade prevents symptom onset in a model of adolescent cannabis abuse
Abstract Cannabis abuse during adolescence confers an increased risk for developing later in life cognitive deficits reminiscent of those observed…
Disease-modifying effects of natural Δ9-tetrahydrocannabinol in endometriosis-associated pain
Abstract Endometriosis is a chronic painful disease highly prevalent in women that is defined by growth of endometrial tissue outside…
Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors
Abstract Activation of cannabinoid CB1 receptors (CB1R) by delta9-tetrahydrocannabinol (THC) produces a variety of negative effects with major consequences in…
Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
Abstract Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this…