The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI
Abstract A central process contributing to the phenotype of aging is cellular senescence. We recently identified the FOXO4 – p53…
Qishun Zhou
EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner
Abstract Millions of people worldwide are affected by neurodegenerative diseases (NDs), and to date, no effective treatment has been reported.…
Phosphorylation Regulates CIRBP Arginine Methylation, Transportin-1 Binding and Liquid-Liquid Phase Separation
Abstract Arginine-glycine(-glycine) (RG/RGG) regions are highly abundant in RNA-binding proteins and involved in numerous physiological processes. Aberrant liquid-liquid phase separation…