Structural basis for specific RNA recognition by the alternative splicing factor RBM5
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of…
Pravin Kumar Ankush Jagtap
Structure and dynamics of the quaternary hunchback mRNA translation repression complex
Abstract A key regulatory process during Drosophila development is the localized suppression of the hunchback mRNA translation at the posterior,…
Divergent evolution toward sex chromosome-specific gene regulation in Drosophila
Abstract In this study, Villa et al. compared the targeting mechanisms of the dosage compensation complex in two Drosophila species,…
Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless
Abstract Maleless (MLE) is an evolutionary conserved member of the DExH family of helicases in Drosophila. Besides its function in…
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
Abstract Alternative pre-messenger ribonucleic acid (pre-mRNA) splicing is an essential process in eukaryotic gene regulation. The T-cell intracellular antigen-1 (TIA-1)…