Philippe A. Melas

December 31, 2022

Synaptoproteomic Analysis of the Prefrontal Cortex Reveals Spatio-Temporal Changes in SYNGAP1 Following Cannabinoid Exposure in Rat Adolescence

Abstract The regular use of cannabis during adolescence has been associated with a number of negative life outcomes, including psychopathology…

February 13, 2021

Cannabidiol as a Potential Treatment for Anxiety and Mood Disorders: Molecular Targets and Epigenetic Insights from Preclinical Research

Abstract Cannabidiol (CBD) is the most abundant non-psychoactive component of cannabis; it displays a very low affinity for cannabinoid receptors,…

April 20, 2020

Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine

Abstract The endocannabinoid system has a modulatory role in brain reward and cognitive processes. It has been hypothesized that repeated…

September 17, 2018

Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood

Abstract Cannabis use is typically initiated during adolescence and is a significant risk factor for the development of cocaine use…

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