Abstract Cereblon/CRBN is a substrate-recognition component of the Cullin4A-DDB1-Roc1 E3 ubiquitin ligase complex. Destabilizing mutations in the human CRBN gene…
Abstract Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical…
Abstract The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased…
Abstract Cannabinoids have shown to exert their therapeutic actions through a variety of targets. These include not only the canonical…
Abstract Endocannabinoids are ancient biomolecules involved in several cellular (e.g., metabolism) and physiological (e.g., eating behaviour) functions. Indeed, eating behaviour…
Abstract Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this…
Abstract The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders,…
Abstract Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of…
Abstract The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and…
Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a…