Glycosylated cannabinoids in Cannabis sativa and enzyme design to modulate their synthesis
Abstract Cannabinoids are the primary active compounds in Cannabis sativa and hold significant medical potential. However, their high lipophilicity limits…
Paula Berman
Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway
Abstract In T-cell acute lymphoblastic leukemia (T-ALL), more than 50% of cases display autoactivation of Notch1 signaling, leading to oncogenic…
Cannabis for Medical Use: Versatile Plant Rather Than a Single Drug
Abstract Medical Cannabis and its major cannabinoids (−)-trans-Δ9-tetrahydrocannabinol (THC) and cannabidiol (CBD) are gaining momentum for various medical purposes as…
Fertilization Following Pollination Predominantly Decreases Phytocannabinoids Accumulation and Alters the Accumulation of Terpenoids in Cannabis Inflorescences
Abstract In the last decades, growing evidence showed the therapeutic capabilities of Cannabis plants. These capabilities were attributed to the…
Sex differences in medical cannabis-related adverse effects
Abstract Supplemental Digital Content is Available in the Text. Women are more susceptible to medical cannabis–related adverse effects because of…
Prolonged Medical Cannabis Treatment is Associated With Quality of Life Improvement and Reduction of Analgesic Medication Consumption in Chronic Pain Patients
Abstract Introduction: Chronic non-cancer pain (CNCP) is one of the most prevalent indications for medical cannabis (MC) treatment globally. In…
Metabolic Profiling of Cannabis Secondary Metabolites for Evaluation of Optimal Postharvest Storage Conditions
Abstract The therapeutic use of medical Cannabis is growing, and so is the need for standardized and therapeutically stable Cannabis…
Cannabis Consumption Used by Cancer Patients during Immunotherapy Correlates with Poor Clinical Outcome
Abstract Simple Summary: Cannabis is widely used by patients with cancer to help with cancer symptoms and treatment side effects.…
Migraine Frequency Decrease Following Prolonged Medical Cannabis Treatment: A Cross-Sectional Study
Abstract Background: Medical cannabis (MC) treatment for migraine is practically emerging, although sufficient clinical data are not available for this…
Full-Spectrum Cannabis Extract Microdepots Support Controlled Release of Multiple Phytocannabinoids for Extended Therapeutic Effect
Abstract The therapeutic effect of the Cannabis plant largely depends on the presence and specific ratio of a spectrum of…