Abstract Positive allosteric modulation of the type 1 cannabinoid receptor (CB1R) has substantial potential to treat both neurological and immune…
Abstract Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical…
Abstract Cannabinoids have been long studied for their therapeutic properties, particularly for their use in the treatment of pain. As…
Abstract The endocannabinoid system has emerged as a promising target for the treatment of numerous diseases, including cancer, neurodegenerative disorders,…
Abstract Transient receptor potential (TRP) channels are a group of membrane proteins involved in the transduction of a plethora of…
Abstract The endocannabinoid system (ECS) has been shown to be of great importance in the regulation of numerous physiological and…
Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a…
Abstract The G protein-coupled receptor (GPCR) superfamily of integral proteins is the largest family of signal transducers, comprised of ∼1000…
Abstract We recently reported on a controlled deactivation/detoxification approach for obtaining cannabinoids with improved druggability. Our design incorporates a metabolically…
Abstract We have recently identified 1,8-naphthyridin-2(1H)-one-3-carboxamide as a new scaffold very suitable for the development of new CB2 receptor potent…