Robust folding of a de novo designed ideal protein even with most of the core mutated to valine
Abstract De novo designed proteins exhibit a remarkable property of extremely high thermal stability compared with naturally occurring proteins. The…
Naohiro Kobayashi
Modern Technologies of Solution Nuclear Magnetic Resonance Spectroscopy for Three-dimensional Structure Determination of Proteins Open Avenues for Life Scientists
Abstract Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique for structural studies of chemical compounds and biomolecules such as…
Structural basis for the sequence-specific RNA-recognition mechanism of human CUG-BP1 RRM3
Abstract The CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-like factors (CELF) family or the Bruno-like…
The RRM domain of poly(A)-specific ribonuclease has a noncanonical binding site for mRNA cap analog recognition
Abstract The degradation of the poly(A) tail is crucial for posttranscriptional gene regulation and for quality control of mRNA. Poly(A)-specific…