Abstract Both metabotropic (CBRs) and ionotropic cannabinoid receptors (ICRs) have implications in a range of neurological disorders. The metabotropic canonical…
Abstract The classical terms agonists and antagonists for G protein coupled receptors (GPCRs) have often become misleading. Even the biased…
Abstract Cannabinoids have shown to exert their therapeutic actions through a variety of targets. These include not only the canonical…
Abstract Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this…
Abstract Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a…
Abstract Endocannabinoids activate two types of specific G-protein-coupled receptors (GPCRs), namely cannabinoid CB1 and CB2. Contrary to the psychotropic actions…
Abstract In 2005, the first evidence of an allosteric binding site at the CB1R was provided by the identification of…