Terpenoids From Cannabis Do Not Mediate an Entourage Effect by Acting at Cannabinoid Receptors
Abstract The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other…
Abstract The entourage effect was a proposed explanation for biological observations that endocannabinoid ligand activities can be modified by other…
Abstract Synthetic cannabinoid receptor agonists (SCRAs) are the largest class of new psychoactive substances (NPS). New examples are detected constantly,…
Abstract Arrestin translocation and signaling have come to the fore of the G protein-coupled receptor molecular pharmacology field. Some receptor–arrestin…
Abstract Introduction:Cannabis biosynthesizes Δ9-tetrahydrocannabinolic acid (THCA-A), which decarboxylates into Δ9-tetrahydrocannabinol (THC). There is growing interest in the therapeutic use of…
Abstract An agonist that acts through a single receptor can activate numerous signaling pathways. Recent studies have suggested that different…
Abstract The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases.…
Abstract Electronic supplementary material: The online version of this article (doi:10.1007/s11419-016-0316-y) contains supplementary material, which is available to authorized users.…
Abstract The orphan receptor GPR18 has become a research target following the discovery of a putative endogenous agonist, N-arachidonoyl glycine…