Structural basis for specific RNA recognition by the alternative splicing factor RBM5
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of…
Michael Sattler
DNA Structure-Specific Cleavage of DNA-Protein Crosslinks by the SPRTN Protease
Abstract Repair of covalent DNA-protein crosslinks (DPCs) by DNA-dependent proteases has emerged as an essential genome maintenance mechanism required for…
Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1
Abstract Post-transcriptional mechanisms play a predominant role in the control of microRNA (miRNA) production. Recognition of the terminal loop of…
A Numb–Mdm2 fuzzy complex reveals an isoform-specific involvement of Numb in breast cancer
Abstract Numb regulates the activity of the tumor suppressor p53 by inhibiting Mdm2. This study from Colaluca et al. highlights…
The EBNA-2 N-Terminal Transactivation Domain Folds into a Dimeric Structure Required for Target Gene Activation
Abstract Epstein-Barr virus (EBV) is a γ-herpesvirus that may cause infectious mononucleosis in young adults. In addition, epidemiological and molecular…
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
Abstract Alternative pre-messenger ribonucleic acid (pre-mRNA) splicing is an essential process in eukaryotic gene regulation. The T-cell intracellular antigen-1 (TIA-1)…