Merging enzymatic and synthetic chemistry with computational synthesis planning
Abstract Synthesis planning programs trained on chemical reaction data can design efficient routes to new molecules of interest, but are…
Mengjie Liu
Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
Abstract UHRF1 is an important epigenetic regulator for maintenance DNA methylation. UHRF1 recognizes hemi-methylated DNA (hm-DNA) and trimethylation of histone…