Abstract Numerous spider venom-derived gating modifier toxins exhibit conformational heterogeneity during purification by reversed-phase high-performance liquid chromatography (RP-HPLC). This conformational…
Abstract Multivalent ligands of ion channels have proven to be both very rare and highly valuable in yielding unique insights…
Abstract Phox homology (PX) domains are membrane interacting domains that bind to phosphatidylinositol phospholipids or phosphoinositides, markers of organelle identity…
Abstract Pausing during transcription elongation is a fundamental activity in all kingdoms of life. In bacteria, the essential protein NusA…
Abstract AIDA1 links persistent chemical signaling events occurring at the neuronal synapse with global changes in gene expression. Consistent with…