Neuroprotection by (Endo)Cannabinoids in Glaucoma and Retinal Neurodegenerative Diseases
Abstract Background: Emerging neuroprotective strategies are being explored to preserve the retina from degeneration, that occurs in eye pathologies like…
Mauro Maccarrone
Metabolism of the Endocannabinoid Anandamide: Open Questions after 25 Years
Abstract Cannabis extracts have been used for centuries, but its main active principle ∆9-tetrahydrocannabinol (THC) was identified about 50 years…
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Abstract The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases.…
Interaction between interleukin-1β and type-1 cannabinoid receptor is involved in anxiety-like behavior in experimental autoimmune encephalomyelitis
Abstract Background: Mood disorders, including anxiety and depression, are frequently diagnosed in multiple sclerosis (MS) patients, even independently of the…
Seventh European Workshop on Cannabinoid Research and IACM Eighth Conference on Cannabinoids in Medicine
Abstract The joint 7th European Workshop on Cannabinoid Research and IACM 8th Conference on Cannabinoids in Medicine was held in…
Activation of GPR55 Receptors Exacerbates oxLDL-Induced Lipid Accumulation and Inflammatory Responses, while Reducing Cholesterol Efflux from Human Macrophages
Abstract The G protein-coupled receptor GPR55 has been proposed as a new cannabinoid receptor associated with bone remodelling, nervous system…
Endocannabinoids, Related Compounds and Their Metabolic Routes
Abstract Endocannabinoids are lipid mediators able to bind to and activate cannabinoid receptors, the primary molecular targets responsible for the…
Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men
Abstract Male infertility is a major cause of problems for many couples in conceiving a child. Recently, lifestyle pastimes such…
Effects of anandamide in migraine: data from an animal model
Abstract Systemic nitroglycerin (NTG) produces spontaneous-like migraine attacks in migraine sufferers and induces a condition of hyperalgesia in the rat…