PYK2 senses calcium through a disordered dimerization and calmodulin-binding element
Abstract Multidomain kinases use many ways to integrate and process diverse stimuli. Here, we investigated the mechanism by which the…
Mariusz Jaremko
Small molecule inhibitors targeting Polycomb Repressive Complex 1 RING domain
Abstract Polycomb repressive complex 1 (PRC1) is an essential chromatin modifying complex that monoubiquitinates histone H2A and is involved in…
BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization
Abstract BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of…