Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
Abstract Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of…
Mariann Bienz
Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control
Abstract Transcriptional silencing through the Polycomb silencing machinery utilizes a “read-write” mechanism involving histone tail modifications. However, nucleation of silencing…