Maria Paola Castelli

August 9, 2022

Adolescent self-administration of the synthetic cannabinoid receptor agonist JWH-018 induces neurobiological and behavioral alterations in adult male mice

Abstract Rationale: The use of synthetic cannabinoid receptor agonists (SCRAs) is growing among adolescents, posing major medical and psychiatric risks.…

June 29, 2021

Repeated exposure to JWH‐018 induces adaptive changes in the mesolimbic and mesocortical dopaminergic pathways, glial cells alterations, and behavioural correlates

Abstract Background and Purpose: Spice/K2 herbal mixtures, containing synthetic cannabinoids such as JWH‐018, have been marketed as marijuana surrogates since…

September 3, 2020

Sex and Gender Differences in the Effects of Novel Psychoactive Substances

Abstract Sex and gender deeply affect the subjective effects and pharmaco-toxicological responses to drugs. Men are more likely than women…

April 27, 2012

Reversible Disruption of Pre-Pulse Inhibition in Hypomorphic-Inducible and Reversible CB1-/- Mice

Abstract Although several genes are implicated in the pathogenesis of schizophrenia, in animal models for such a severe mental illness…