CD93 in Health and Disease: Bridging Physiological Functions and Clinical Applications
Abstract CD93 is a highly glycosylated transmembrane glycoprotein with key functional domains, including a C-type lectin-like domain (CTLD) and epidermal…
Li Ye
Targeting collagen in tumor extracellular matrix as a novel targeted strategy in cancer immunotherapy
Abstract Collagen, the most abundant protein in mammal, is widely expressed in tissues and organs, as well as tumor extracellular…
A SIRPαFc Fusion Protein Conjugated With the Collagen-Binding Domain for Targeted Immunotherapy of Non-Small Cell Lung Cancer
Abstract The SIRPαFc fusion protein can block the immunosuppressive CD47-SIRPα signal between macrophages and tumor cells as a decoy receptor…