Structural basis for specific RNA recognition by the alternative splicing factor RBM5
Abstract The RNA-binding motif protein RBM5 belongs to a family of multi-domain RNA binding proteins that regulate alternative splicing of…
Komal Soni
Mechanistic insights into RNA surveillance by the canonical poly(A) polymerase Pla1 of the MTREC complex
Abstract The S. pombe orthologue of the human PAXT connection, Mtl1-Red1 Core (MTREC), is an eleven-subunit complex that targets cryptic…
The zinc-finger protein Red1 orchestrates MTREC submodules and binds the Mtl1 helicase arch domain
Abstract Cryptic unstable transcripts (CUTs) are rapidly degraded by the nuclear exosome in a process requiring the RNA helicase Mtr4…