CB1 cannabinoid receptor agonists induce acute respiratory depression in awake mice☆
Abstract Recreational use of synthetic cannabinoid agonists (i.e., “spice compounds”) that target the cannabinoid type 1 receptor (CB1) can cause…
Ken Mackie
Reelin Deficiency and Synaptic Impairment in the Adolescent Prefrontal Cortex Following Initial Synthetic Cannabinoid Exposure
Abstract Background: Adolescent cannabinoid exposure can have long-lasting effects on the brain, particularly in the prefrontal cortex, where the reelin…
Hexahydrocannabinol (HHC) and Δ9-tetrahydrocannabinol (Δ9-THC) driven activation of cannabinoid receptor 1 results in biased intracellular signaling
Abstract The Cannabis sativa plant has been used for centuries as a recreational drug and more recently in the treatment…
CB1 Receptor Negative Allosteric Modulators as a Potential Tool to Reverse Cannabinoid Toxicity
Abstract While the opioid crisis has justifiably occupied news headlines, emergency rooms are seeing many thousands of visits for another…
SGIP1 in axons prevents internalization of desensitized CB1R and modifies its function
Abstract In the central nervous system (CNS), cannabinoid receptor 1 (CB1R) is preferentially expressed in axons where it has a…
The modulatory role of cannabis use in subconcussive neural injury
Abstract Cannabis use has become popular among athletes, many of whom are exposed to repetitive subconcussive head impacts. We aimed…
A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model
Abstract In addition to phytocannabinoids, cannabis contains terpenoids that are claimed to have a myriad of effects on the body.…
Adolescent administration of Δ9-THC decreases the expression and function of muscarinic-1 receptors in prelimbic prefrontal cortical neurons of adult male mice
Abstract Long-term cannabis use during adolescence has deleterious effects in brain that are largely ascribed to the activation of cannabinoid-1…
An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
Abstract Cannabis contains more than 100 phytocannabinoids. Most of these remain poorly characterized, particularly in neurons. We tested a panel…
GPR18 drives FAAH inhibition-induced neuroprotection against HIV-1 Tat-induced neurodegeneration
Abstract Human immunodeficiency virus type 1 (HIV-1) is known to provoke microglial immune responses which likely play a paramount role…