Cannabidiol Impairs Brain Mitochondrial Metabolism and Neuronal Integrity
Abstract Background: The mechanisms underlying the clinical effects of CBD remain poorly understood. Given the increasing evidence for CBD’s effects…
Keith A. Sharkey
Role of the Endocannabinoid System in the Regulation of Intestinal Homeostasis
Abstract The maintenance of intestinal homeostasis is fundamentally important to health. Intestinal barrier function and immune regulation are key determinants…
Insights into the role of cannabis in the management of inflammatory bowel disease
Abstract Over the last decade, interest in the therapeutic potential of cannabis and its constituents (e.g. cannabidiol) in the management…
Nausea-Induced 5-HT Release in the Interoceptive Insular Cortex and Regulation by Monoacylglycerol Lipase (MAGL) Inhibition and Cannabidiol
Abstract Using the rat conditioned gaping model of nausea, the interoceptive insular cortex (IIC) has been identified as a critical…
Abnormal cannabidiol attenuates experimental colitis in mice, promotes wound healing and inhibits neutrophil recruitment
Abstract Background: Non-psychotropic atypical cannabinoids have therapeutic potential in a variety of inflammatory conditions including those of the gastrointestinal tract.…
Prevention of Diet-Induced Obesity Effects on Body Weight and Gut Microbiota in Mice Treated Chronically with Δ9-Tetrahydrocannabinol
Abstract Objective: Acute administration of cannabinoid CB1 receptor agonists, or the ingestion of cannabis, induces short-term hyperphagia. However, the incidence…
A role for O-1602 and G protein-coupled receptor GPR55 in the control of colonic motility in mice
Abstract Objective: The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid (CB) receptor, whose role in the gastrointestinal (GI)…