Peptide exchange on MHC-I by TAPBPR is driven by a negative allostery release cycle
Abstract Chaperones TAPBPR and tapasin associate with class-I major histocompatibility complexes (MHC-I) to promote optimization (editing) of peptide cargo. Here,…
Kannan Natarajan
An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role
Abstract The molecular mechanism through which the interaction of a clonotypic αβ T-cell receptor (TCR) with a peptide-loaded major histocompatibility…