K. P. C. Kuypers

October 13, 2022

Cannabis containing equivalent concentrations of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) induces less state anxiety than THC-dominant cannabis

Abstract Rationale: Delta-9-tetrahydrocannabinol (THC), an active component of cannabis, can cause anxiety in some users during intoxication. Cannabidiol (CBD), another…

November 16, 2017

Peripheral endocannabinoid concentrations are not associated with verbal memory impairment during MDMA intoxication

Abstract Background: Preclinical data have suggested involvement of the endocannabinoid (eCB) system in MDMA-induced memory impairment. Clinical research has shown…

July 15, 2016

Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure

Abstract Rationale: Alcohol and cannabis use have been implicated in aggression. Alcohol consumption is known to facilitate aggression, whereas a…

May 26, 2016

Cannabis and tolerance: acute drug impairment as a function of cannabis use history

Abstract Cannabis use history as predictor of neurocognitive response to cannabis intoxication remains subject to scientific and policy debates. The…

December 14, 2015

Cannabis and cocaine decrease cognitive impulse control and functional corticostriatal connectivity in drug users with low activity DBH genotypes

Abstract The dopamine β-hydroxylase (DβH) enzyme transforms dopamine into noradrenaline. We hypothesized that individuals with low activity DBH genotypes (rs1611115…

May 13, 2012

A placebo-controlled study to assess Standardized Field Sobriety Tests performance during alcohol and cannabis intoxication in heavy cannabis users and accuracy of point of collection testing devices for detecting THC in oral fluid

Abstract Rationale: Standardized Field Sobriety Tests (SFST) and oral fluid devices are used to screen for driving impairment and roadside…