DNA methylation, but not microRNA expression, is affected by in vitro THC exposure in bovine granulosa cells
Abstract Background: A global increase in cannabis use has led to questions about its effects on fertility. The rise in…
Jibran Y. Khokhar
THC and sperm: Impact on fertilization capability, pre-implantation in vitro development and epigenetic modifications
Abstract Global cannabis use has risen 23% since 2010, with 209 million reported users, most of whom are males of…
Sperm capacitation and transcripts levels are altered by in vitro THC exposure
Abstract Background: Delta-9-tetrahydrocannabinol (THC) is the primary phytocannabinoid responsible for the psychoactive properties of cannabis and is known to interact…
Discordant Effects of Cannabinoid 2 Receptor Antagonism/Inverse Agonism During Adolescence on Pavlovian and Instrumental Reward Learning in Adult Male Rats
Abstract The endocannabinoid system is responsible for regulating a spectrum of physiological activities and plays a critical role in the…
Sex-Specific Cannabidiol- and Iloperidone-Induced Neuronal Activity Changes in an In Vitro MAM Model System of Schizophrenia
Abstract Cortical circuit dysfunction is thought to be an underlying mechanism of schizophrenia (SZ) pathophysiology with normalization of aberrant circuit…
Effects of Delta-9 Tetrahydrocannabinol (THC) on Oocyte Competence and Early Embryonic Development
Abstract Recent changes in legal status and public perception of cannabis have contributed to an increase use amongst women of…
Cannabis Use and Mental Illness: Understanding Circuit Dysfunction Through Preclinical Models
Abstract Patients with a serious mental illness often use cannabis at higher rates than the general population and are also…
A novel allosteric modulator of the cannabinoid CB1 receptor ameliorates hyperdopaminergia endophenotypes in rodent models
Abstract The endocannabinoid system (eCBs) encompasses the endocannabinoids, their synthetic and degradative enzymes, and cannabinoid (CB) receptors. The eCBs mediates…