A cross-cohort computational framework to trace tumor tissue-of-origin based on RNA sequencing
Abstract Carcinoma of unknown primary (CUP) is a type of metastatic cancer with tissue-of-origin (TOO) unidentifiable by traditional methods. CUP…
Jianjun He
Bioinformatics analysis for the role of CALR in human cancers
Abstract Cancer is one of the most important public health problems in the world. The curative effect of traditional surgery,…
Pan-Cancer Analysis of the Mitophagy-Related Protein PINK1 as a Biomarker for the Immunological and Prognostic Role
Abstract Introduction: The PINK1 gene encodes a serine/threonine protein kinase that localizes to mitochondria and has usually been considered to…
TOOme: A Novel Computational Framework to Infer Cancer Tissue-of-Origin by Integrating Both Gene Mutation and Expression
Abstract Metastatic cancers require further diagnosis to determine their primary tumor sites. However, the tissue-of-origin for around 5% tumors could…