Attribution of Cancer Origins to Endogenous, Exogenous, and Preventable Mutational Processes
Abstract Mutational processes in tumors create distinctive patterns of mutations, composed of neutral “passenger” mutations and oncogenic drivers that have…
Jeffrey P. Townsend
Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Abstract Cancers harbor many somatic mutations and germline variants, we hypothesized that the combined effect of germline variants that alter…