Abstract Supplementary Information: The online version contains supplementary material available at 10.1038/s41598-025-31042-w. Article type: Research Article Keywords: Pan-cancer, E2F family,…
Abstract Background: In the realm of tumor-targeted therapeutics, Polo-like kinases (PLKs) are a significant group of protein kinases that were…
Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of…
Abstract Background: Deubiquitinating enzymes specifically removes ubiquitin molecules from ubiquitin-tagged target proteins, thereby inhibiting the degradation of target proteins and…