Profiling bile acid composition in bile from mice of different ages and sexes
Abstract Introduction: Bile BA profiling is important for understanding the pathogenetic mechanisms underlying gallbladder and gastrointestinal diseases. Until now, bile…
Hongwei Jiang
Annexin A1-FPR1 Interaction in dendritic cells promotes immune microenvironment modulation in Thyroid Cancer
Abstract Supplementary Information: The online version contains supplementary material available at 10.1007/s10565-025-10042-6. Article type: Research Article Keywords: Thyroid Cancer, Tumor…
Distinct circulating monocyte profiles in chronic cannabis users compared to cocaine users without changes in plasma levels of proinflammatory cytokines and LPS
Abstract Objectives: Chronic cannabis use is linked to anti-inflammatory effects, and cocaine exhibits context-dependent immunomodulation; their distinct impacts on monocyte…
Toxicological evaluation of porcine bile powder in Kunming mice and Sprague–Dawley rats
Abstract Background: Porcine bile powder (PBP) is a traditional Chinese medicine that has been used for centuries in various therapeutic…
Comparative profiling of serum, urine, and feces bile acids in humans, rats, and mice
Abstract Bile acids (BAs) play important pathophysiological roles in both humans and mammalian animals. Laboratory rats and mice are widely…
Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice
Abstract Background: Some evidence suggests that cannabidiol (CBD) has potential to help alleviate HIV symptoms due to its antioxidant and…
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARα nucleus-cytoplasm shuttling
Abstract Nonalcoholic fatty liver disease (NAFLD) is usually characterized with disrupted bile acid (BA) homeostasis. However, the exact role of…
Comprehensive pan-cancer analysis of N7-methylguanosine regulators: Expression features and potential implications in prognosis and immunotherapy
Abstract Although immunotherapy has made great strides in cancer therapy, its effectiveness varies widely among individual patients as well as…
Targeted metabolomics reveals aberrant profiles of serum bile acids in patients with schizophrenia
Abstract Emerging evidence indicates that bile acids (BAs), which are signaling molecules that regulate metabolism and inflammation, appear to be…
GATA binding protein 1 recruits histone deacetylase 2 to the promoter region of nuclear receptor binding protein 2 to affect the tumor microenvironment and malignancy of thyroid carcinoma
Abstract The tumor microenvironment (TME) and activated angiogenesis in thyroid carcinoma (TC) are critical for tumor growth and metastasis. Nuclear…