SUGT1 regulates the progression of ovarian cancer through the AKT/PI3K/mTOR signaling pathway
Abstract Macroscopic analysis of SUGT1 and cancer prognosis. ELF1 stimulates the transcription of SUGT1 through the PI3K/AKT pathway. SUGT1 promote…
Hongjie Xu
Pan-cancer Multi-omics Analysis Reveals HMGN1 as a Potential Prognostic and Immune Infiltration-associated Biomarker
Abstract Background: The High Mobility Group Nucleosomal Binding Domain 1 Gene (HMGN1) is crucial for epigenetic regulation. However, the specific…
The Underlying Changes in Serum Metabolic Profiles and Efficacy Prediction in Patients with Extensive Ulcerative Colitis Undergoing Fecal Microbiota Transplantation
Abstract (1) Background: Fecal microbiota transplantation (FMT) is an effective treatment for ulcerative colitis (UC). Metabolomic techniques would assist physicians…
NALCN is a potential biomarker and therapeutic target in human cancers
Abstract Background: Sodium leak channel non-selective (NALCN), known as a voltage-independent Na+ channel, is increasingly considered to play vital roles…
Effects of dietary tryptophan on the antioxidant capacity and immune response associated with TOR and TLRs/MyD88/NF-κB signaling pathways in northern snakehead, Channa argus (Cantor, 1842)
Abstract Introduction: Dietary tryptophan (Trp) has been shown to influence fish feed intake, growth, immunity and inflammatory responses. The purpose…
Neuroprotection of cannabidiol in epileptic rats: Gut microbiome and metabolome sequencing
Abstract Aims: Epilepsy is a neurological disease occurring worldwide. Alterations in the gut microbial composition may be involved in the…
Pressure-induced structural transformations and polymerization in ThC2
Abstract Thorium-carbon systems have been thought as promising nuclear fuel for Generation IV reactors which require high-burnup and safe nuclear…
Structural Phase Transition of ThC Under High Pressure
Abstract Thorium monocarbide (ThC) as a potential fuel for next generation nuclear reactor has been subjected to its structural stability…
Acute upregulation of neuronal mitochondrial type-1 cannabinoid receptor and it’s role in metabolic defects and neuronal apoptosis after TBI
Abstract Metabolic defects and neuronal apoptosis initiated by traumatic brain injury (TBI) contribute to subsequent neurodegeneration. They are all regulated…