Delta-9-tetrahydrocannabinol reduces willingness to exert effort in women
Abstract Background: The use of cannabis has been clinically associated with decreased motivation to engage in normally rewarding activities. However,…
Harriet de Wit
Δ9-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial
Abstract With the increasing prevalence of legal cannabis use and availability, there is an urgent need to identify cognitive impairments…
Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders
Abstract Liability to alcohol dependence (AD) is heritable, but little is known about its complex polygenic architecture or its genetic…
Cannabidiol Does Not Dampen Responses to Emotional Stimuli in Healthy Adults
Abstract Introduction: Cannabidiol (CBD) is a nonpsychoactive constituent of whole plant cannabis that has been reported to reduce anxiety-like behaviors…
A Preliminary Investigation of Individual Differences in Subjective Responses to D-Amphetamine, Alcohol, and Delta-9-Tetrahydrocannabinol Using a Within-Subjects Randomized Trial
Abstract Trial Registration: ClinicalTrials.gov NCT02485158 Authors: Margaret C. Wardle, Benjamin A. Marcus, Harriet de Wit Affiliations: Center for Neurobehavioral Research…
Cannabinoid Modulation of Amygdala Subregion Functional Connectivity to Social Signals of Threat
Abstract Background: Δ9-Tetrahydrocannabinol has been shown to modulate anxiety and facilitate the extinction of fear by inhibiting amygdala reactivity. Since…
Psychoactive drugs and false memory: comparison of dextroamphetamine and delta-9-tetrahydrocannabinol on false recognition
Abstract Rationale: Several psychoactive drugs are known to influence episodic memory. However, these drugs’ effects on false memory, or the…