A pan-cancer analysis of lipid metabolic alterations in primary and metastatic cancers
Abstract Metabolic reprogramming is a hallmark of cancers, but pan-cancer level roles of lipid metabolism in cancer development are remains…
Guojun Liu
Pan-cancer analysis of DEPDC1 as a candidate prognostic biomarker and associated with immune infiltration
Abstract Background: DEP domain containing 1 (DEPDC1) gene is upregulated in several malignancies and contributes to tumorigenesis. Although the role…
Pan-cancer analysis identifies migrasome-related genes as a potential immunotherapeutic target: A bulk omics research and single cell sequencing validation
Abstract Introduction: The migrasome is a newly discovered organelle that resembles extracellular vesicles in structure. However, the function of the…
Genome-wide identification of key enzyme-encoding genes and the catalytic roles of two 2-oxoglutarate-dependent dioxygenase involved in flavonoid biosynthesis in Cannabis sativa L.
Abstract Background: Flavonoids are necessary for plant growth and resistance to adversity and stress. They are also an essential nutrient…
Prognostic Value of UBE2T and Its Correlation with Immune Infiltrates in Lung Adenocarcinoma
Abstract Non-small cell lung cancer has a subtype with a high morbidity and mortality rate called lung adenocarcinoma (LUAD). It…
An integrative analysis revealing POLD2 as a tumor suppressive immune protein and prognostic biomarker in pan-cancer
Abstract Introduction: POLD2 is an indispensable subunit of DNA polymerase δ, which is responsible for the synthesis of the backward…
Clinical significance of cyclin-dependent kinase inhibitor 2C expression in cancers: from small cell lung carcinoma to pan-cancers
Abstract Background: Cyclin-dependent kinase inhibitor 2C (CDKN2C) was identified to participate in the occurrence and development of multiple cancers; however,…
The Prognostic and Immunotherapeutic Significance of AHSA1 in Pan-Cancer, and Its Relationship With the Proliferation and Metastasis of Hepatocellular Carcinoma
Abstract The AHSA1 is a main activator of ATPase of Hsp90. Hsp90 is involved in various metabolic and developmental processes…
Ogt Demonstrated Conspicuous Clinical Significance in Cancers, from Pan-Cancer to Small-Cell Lung Cancer
Abstract The clinical progression of small-cell lung cancer (SCLC) remains pessimistic. The aim of the present study was to promote…
Identification of the Histone Deacetylases Gene Family in Hemp Reveals Genes Regulating Cannabinoids Synthesis
Abstract Histone deacetylases (HDACs) play crucial roles nearly in all aspects of plant biology, including stress responses, development and growth,…