Multi-dimensional analysis reveals the potential of PDK4 as a tumor biomarker and target for immunotherapy
Abstract Purpose: To explore the clinical significance of pyruvate dehydrogenase kinase 4 (PDK4) in pan-cancer and its potential as a…
Guixin Wang
Endoscopic retrograde cholangiopancreatography for the treatment of common bile duct dilatation with choledocholithiasis in children: a single-center retrospective cohort study of 58 cases
Abstract Background: Congenital biliary dilatation (CBD) represents a prevalent congenital anomaly in pediatric surgery, with concurrent choledocholithiasis observed in a…
Flexural Behavior of Orthotropic Steel–LUHPC Composite Bridge Decks: Experimental and Numerical Study
Abstract Orthotropic Steel Bridge Decks (OSBDs) are often used in long-span bridges due to their high performance and ease of…
Systematic Characterisation and Analysis of Lysyl Oxidase Family Members as Drivers of Tumour Progression and Multiple Drug Resistance
Abstract The intricacies of tumour microenvironment, particularly the extracellular matrix (ECM), underscore its pivotal function in modulating tumour progression and…
Potential tumor-specific antigens and immune landscapes identification for mRNA vaccine in thyroid cancer
Abstract Background: Tumor mRNA vaccines have been identified as a promising technology for cancer therapy in multiple cancer types, while…
Structural Optimization of Cannabidiol as Multifunctional Cosmetic Raw Materials
Abstract Cannabidiol (CBD), derived from the plant cannabis, can be used in the cosmetics industry for its antioxidant, anti-inflammatory, anti-wrinkle…
Benefits of Huang Lian mediated by gut microbiota on HFD/STZ-induced type 2 diabetes mellitus in mice
Abstract Background: Huang Lian (HL), one of the traditional Chinese medicines (TCMs) that contains multiple active components including berberine (BBR),…
APOBEC-mediated mutagenesis is a favorable predictor of prognosis and immunotherapy for bladder cancer patients: evidence from pan-cancer analysis and multiple databases
Abstract Background: The APOBEC (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like) family-mediated mutagenesis is widespread in human cancers. However, our…
RUNX1 is a promising prognostic biomarker and related to immune infiltrates of cancer-associated fibroblasts in human cancers
Abstract Background: Runt-related transcription factor 1 (RUNX1) is a vital regulator of mammalian expression. Despite multiple pieces of evidence indicating…
Pan-Cancer Analyses Reveal Oncogenic and Immunological Role of PLOD2
Abstract Some previous studies have shown that PLOD2 has some value in tumorigenesis. However, the broad significance of PLOD2 has…