Data-driven universal insights into tumorigenesis via hallmark networks
Abstract Cancers are complex diseases characterized by dynamic perturbations of regulatory networks across multiple hierarchical levels, which cannot be fully…
Guangyan Wu
A pan-cancer analysis of homeobox family: expression characteristics and latent significance in prognosis and immune microenvironment
Abstract Background: The Homeobox (HOX) gene family are conserved transcription factors that are essential for embryonic development, oncogenesis, and cancer…
Construction of novel 7 integrin-related gene signatures in thyroid cancer construction of model based on integrin genes
Abstract Advanced and metastatic THCA patients usually have a poor prognosis. Thus, this study aimed to establish a risk model…
Prediction of Response to Radiotherapy by Characterizing the Transcriptomic Features in Clinical Tumor Samples across 15 Cancer Types
Abstract Purpose: Radiotherapy (RT) is one of the major cancer treatments. However, the responses to RT vary among individual patients,…
Calmodulin dissociates the STIM1-Orai1 complex and STIM1 oligomers
Abstract Store-operated calcium entry (SOCE) is a major pathway for calcium ions influx into cells and has a critical role…