Guangle Zhang

November 29, 2022

A network medicine approach for identifying diagnostic and prognostic biomarkers and exploring drug repurposing in human cancer

Keywords: Systems medicine, Drug repositioning, Network oncology, Gene prioritization, Machine learning, Pan-cancer diagnosis and prognosis Authors: Le Zhang, Shiwei Fan,…

January 25, 2020

Discovering Cancer-Related miRNAs from miRNA-Target Interactions by Support Vector Machines

Abstract MicroRNAs (miRNAs) have been shown to be closely related to cancer progression. Traditional methods for discovering cancer-related miRNAs mostly…

October 16, 2018

Discovering the ‘Dark matters’ in expression data of miRNA based on the miRNA-mRNA and miRNA-lncRNA networks

Abstract Background: Since miRNAs can play important roles in different cancer types, how to discover cancer related miRNAs is an…

May 1, 2018

Identification of cancer-related miRNA-lncRNA biomarkers using a basic miRNA-lncRNA network

Abstract LncRNAs are regulatory noncoding RNAs that play crucial roles in many biological processes. The dysregulation of lncRNA is thought…