Anticancer effect of minor phytocannabinoids in preclinical models of multiple myeloma
Abstract Multiple myeloma (MM) is a blood cancer caused by uncontrolled growth of clonal plasmacells. Bone disease is responsible for…
Giorgio Santoni
Cannabigerol Induces Autophagic Cell Death by Inhibiting EGFR-RAS Pathways in Human Pancreatic Ductal Adenocarcinoma Cell Lines
Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most frequent infiltrating type of pancreatic cancer. The poor prognosis associated with this…
The effects of cannabidiol via TRPV2 channel in chronic myeloid leukemia cells and its combination with imatinib
Abstract Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by accumulation of immature cells in bone marrow and peripheral…
Cannabidiol and Oxygen-Ozone Combination Induce Cytotoxicity in Human Pancreatic Ductal Adenocarcinoma Cell Lines
Abstract Simple Summary: Pancreatic cancer (PC) is related to lifestyle risks, chronic inflammation, and germline mutations. Surgical resection and adjuvant…
The Effects of Cannabidiol and Prognostic Role of TRPV2 in Human Endometrial Cancer
Abstract Several studies support, both in vitro and in vivo, the anti-cancer effects of cannabidiol (CBD), a transient receptor potential…
Transient Receptor Potential Cation Channels in Cancer Therapy
Abstract In mammals, the transient receptor potential (TRP) channels family consists of six different families, namely TRPC (canonical), TRPV (vanilloid),…
Cannabinoids synergize with carfilzomib, reducing multiple myeloma cells viability and migration
Abstract Several studies showed a potential anti-tumor role for cannabinoids, by modulating cell signaling pathways involved in cancer cell proliferation,…
Loss of TRPV2 Homeostatic Control of Cell Proliferation Drives Tumor Progression
Abstract Herein we evaluate the involvement of the TRPV2 channel, belonging to the Transient Receptor Potential Vanilloid channel family (TRPVs),…