Capturing the catalytic intermediates of parkin ubiquitination
Abstract Dysfunction of the E3 ligase parkin is causative for early-onset Parkinson’s disease. Parkin accepts ubiquitin from an E2 conjugating…
Gary S. Shaw
Ubiquitin Interacting Motifs: Duality Between Structured and Disordered Motifs
Abstract Ubiquitin is a small protein at the heart of many cellular processes, and several different protein domains are known…
Selective Recruitment of an E2∼Ubiquitin Complex by an E3 Ubiquitin Ligase*
Abstract Background: Rbx1/ROC1 is an E3 ligase adaptor protein that functions with the E2 enzyme CDC34. Results: NMR and biochemical…