Learning and actioning general principles of cancer cell drug sensitivity
Abstract High-throughput screening of drug sensitivity of cancer cell lines (CCLs) holds the potential to unlock anti-tumor therapies. In this…
Francesco Raimondi
Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm
Abstract Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or…
Profiling of Epigenetic Features in Clinical Samples Reveals Novel Widespread Changes in Cancer
Abstract Aberrations in histone post-translational modifications (PTMs), as well as in the histone modifying enzymes (HMEs) that catalyze their deposition…